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Like many highly pro tein-bound drugs, phenytoin is considered to be restrictively eliminated: only the free fraction is avail able for elimination. Consequently, clearance will in?Jan 4, 2014 · Albumin affinity constant was calculated from theoretical formula using the unbound fraction and serum albumin concentration 1. The results are summarized in Table~In patients with hypoalbuminemia, a corrected equation must be used to account for reduced phenytoin protein binding. This calculator uses the revised versions of the Winter-Tozer